BioCompounds360 - Estrategias integradas para la salud humana y la agricultura sostenible

Abstract

El proyecto "BioCompounds360 - Estrategias Integradas para la Salud Humana y la Agricultura Sostenible" aborda la salud humana y la agricultura sostenible mediante el estudio de compuestos bioactivos. Se enfoca en tres areas: enfermedades neurodegenerativas, control de plagas y resistencia bacteriana. En enfermedades neurodegenerativas, el objetivo es desarrollar inhibidores de colinesterasas (AChE y BChE), cruciales en patologias como el Alzheimer (EA), caracterizada por la sobreactivacion de estas enzimas, que afecta la comunicacion neuronal y fomenta la formacion de placas beta-amiloides. Se utilizaran peptidos de la piel de anfibios y metabolitos de plantas medicinales, asi como péptidos sinteticos. Se pretende buscar inhibidores multiobjetivo para modular diversas vias patologicas. En control de plagas, se desarrollaran alternativas sostenibles a los pesticidas sinteticos con peptidos como bioplaguicidas, que inhiban colinesterasas en plagas y posean propiedades antimicrobianas, reduciendo asi el uso de fertilizantes y el impacto ambiental. El laboratorio ya ha aislado y sintetizado peptidos con actividad inhibitoria reversible de colinesterasas, siendo prometedores bioplaguicidas. En lo que respecta a la resistencia bacteriana, la investigacion se enfocara en identificar y optimizar peptidos con actividad antibacteriana contra cepas patogenas, relevantes para la salud humana. Los Peptidos Antimicrobianos (PAMs) son ideales debido a su amplio espectro de actividad y diferente modo de accion frente a los antibioticos convencionales. Se evaluara la citotoxicidad y toxicidad in vivo de todos los peptidos para garantizar su seguridad y potencial terapeutico. El proyecto se basa en la solida trayectoria de investigacion en peptidos bioactivos que tiene el Departamento de Quimica Organica de la FBCB. Desde los anos 90, se han desarrollado y patentado peptidos y antigenos sinteticos con aplicaciones en salud y biotecnologia. A finales de los 2000, en colaboracion con otros investigadores, se comenzaron a explorar los PAMs en anfibios del Litoral argentino, identificando peptidos con diversas actividades biológicas como inhibicion enzimatica, actividad anticancerigena y antimicrobiana. "BioCompounds360" es un esfuerzo interdisciplinario que aborda problemas criticos en salud, agricultura y medio ambiente mediante la exploracion de compuestos naturales, buscando asi desarrollar tratamientos para el Alzheimer, combatir la resistencia bacteriana y promover practicas agricolas sostenibles.

The project "BioCompounds360 - Integrated Strategies for Human Health and Sustainable Agriculture" addresses human health and sustainable agriculture through the study of bioactive compounds. It focuses on three areas: neurodegenerative diseases, pest control, and bacterial resistance. In neurodegenerative diseases, the goal is to develop cholinesterase inhibitors (AChE and BChE), crucial in conditions such as Alzheimers Disease (AD), characterized by the overactivation of these enzymes, which affects neuronal communication and promotes the formation of β-amyloid plaques. They utilize peptides from amphibian skin and metabolites from medicinal plants, as well as synthetic peptides. They aim to develop multitarget inhibitors to modulate various pathological pathways. In pest control, they develop sustainable alternatives to synthetic pesticides using peptides as biopesticides, which inhibit cholinesterases in pests and have antimicrobial properties, thus reducing the use of fertilizers and environmental impact. The laboratory has isolated and synthesized peptides with reversible cholinesterase inhibitory activity, promising as biopesticides. In bacterial resistance, the research focuses on identifying and optimizing peptides with antibacterial activity against pathogenic strains, relevant to human and animal health. Antimicrobial Peptides (AMPs) are ideal due to their broad spectrum of activity and different mode of action compared to conventional antibiotics. The cytotoxicity and in vivo toxicity of these peptides will be evaluated to ensure their safety and therapeutic potential. The project is based on a solid history of research on bioactive peptides in the Department of Organic Chemistry at FBCB. Since the 1990s, they have developed and patented peptides and synthetic antigens with applications in health and biotechnology. In the late 2000s, in collaboration with other researchers, they began exploring AMPs in amphibians from the Argentine Littoral, identifying peptides with various biological activities such as enzymatic inhibition, anticancer activity, and antimicrobial activity."BioCompounds360" is an interdisciplinary effort that addresses critical problems in health, agriculture, and the environment through the exploration of natural compounds, aiming to develop treatments for Alzheimer?s, combat bacterial resistance, and promote sustainable agricultural practices.